Horn Folkert K, Mardin Christian Y, Viestenz Arne, Jünemann Anselm G
Department of Ophthalmology and University Eye Hospital, Friedrich-Alexander University Erlangen-Nürnberg at Erlangen, Germany.
J Glaucoma. 2005 Dec;14(6):419-25. doi: 10.1097/01.ijg.0000185619.06540.aa.
To perform a correlation between morphology and function by studying local perimetric field losses and thickness reduction of the nerve layer in corresponding areas.
Forty-seven patients with "preperimetric" open-angle glaucoma, 95 patients with "perimetric" open-angle glaucoma, and 75 control subjects had perimetric (Octopus) and polarimetric measurements. Criteria for exclusion: optic discs larger than 4 mm, media opacities, polarimetric hourglass pattern in the macular image. Thickness values of the retinal nerve fiber layer were determined in 14 upper and 14 lower sectors (10 degrees each) as well as nasally and temporally (40 degrees each) as provided from the GDx (software version 4000). The healthy control subjects served to determine age-corrected thickness deviation in all sectors. Analyses were calculated in eight nerve fiber bundle related areas. Due to non-linear relationships between perimetric defects and corresponding thickness deviation non-parametric tests were used.
Localized visual field defects in the present perimetric patients were highest in upper and lower visual field areas abutting the nasal meridian. Thickness loss of nerve fiber layer however was highest in more circumferential upper and lower nerve fiber bundles. Correlations between local mean defects and deviation of the retinal nerve fiber layer thickness from normals showed a clear association for corresponding areas. The correlation coefficients were significant (P < 0.01) for all arcuate superior and inferior visual field zones except horizontally and not for the area of the lower nasal step.
The present correspondence map indicates that focal perimetric defects can be identified best polarimetrically if they occur in the arcuate bundles of the visual field. A lack of correspondence was observed in the area of the papillo-macular bundle.
通过研究局部视野缺损与相应区域神经层厚度减少之间的关系，来实现形态与功能的相关性分析。
对47例“视野检查前”开角型青光眼患者、95例“视野检查时”开角型青光眼患者和75例对照者进行了视野（Octopus）和偏振测量。排除标准：视盘大于4mm、介质混浊、黄斑图像中的偏振沙漏模式。视网膜神经纤维层的厚度值在GDx（软件版本4000）提供的14个上象限和14个下象限（各10度）以及鼻侧和颞侧（各40度）进行测定。健康对照者用于确定所有象限经年龄校正后的厚度偏差。在八个与神经纤维束相关的区域进行分析。由于视野缺损与相应厚度偏差之间存在非线性关系，因此使用了非参数检验。
在当前视野检查的患者中，紧邻鼻子午线的上、下视野区域的局部视野缺损最为严重。然而，神经纤维层的厚度损失在更周向的上、下神经纤维束中最为严重。局部平均缺损与视网膜神经纤维层厚度与正常厚度偏差之间的相关性在相应区域显示出明显的关联。除水平方向外，所有弓形上、下视野区域的相关系数均具有显著性（P < 0.01），而下鼻侧阶梯区域则无显著性。
本对应图表明，如果视野中的弓形束出现局灶性视野缺损，通过偏振测量能最好地识别出来。在视乳头黄斑束区域观察到缺乏对应关系。
