Secondary (non-GpC) binding sites for actinomycin on DNA.
作者信息
Waterloh K, Fox K R
机构信息
Department of Physiology and Pharmacology, University of Southampton, UK.
出版信息
Biochim Biophys Acta. 1992 Jul 15;1131(3):300-6. doi: 10.1016/0167-4781(92)90028-x.
PMID:1627645
Abstract
Actinomycin D has long been known to bind selectively to the dinucleotide step GpC. We have investigated its ability to bind to other non-canonical sequences using a series of synthetic DNA fragments. DNase I footprinting experiments reveal that actinomycin can also bind well to GG (CC). Binding to this sequence and the canonical GC site is potentiated by flanking regions of (GT)n.(AC)n. Weaker but specific binding to GT and AC is also evident and appears to be cooperative.
摘要
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