Mehr R, Agur Z
Department of Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
Biosystems. 1992;26(4):231-7. doi: 10.1016/0303-2647(92)90028-w.
In the process of hemopoiesis, bone marrow stem cells differentiate into the various types of mature blood cells. We present a model for bone marrow dynamics, which retrieves its ability to continuously modulate the balance between self-renewal and differentiation, even under periodic cytodestructive perturbations. Yet, a temporally stochastic perturbation results in chaotic-like behaviour which has no deterministic source.
在造血过程中，骨髓干细胞分化为各种类型的成熟血细胞。我们提出了一个骨髓动力学模型，该模型即使在周期性细胞破坏扰动下，仍能恢复其持续调节自我更新和分化之间平衡的能力。然而，一个时间上随机的扰动会导致类似混沌的行为，而这种行为没有确定性来源。
