Bab I A, Einhorn T A
Bone Laboratory, Faculty of Dental Medicine, Hebrew University of Jerusalem, Israel.
Crit Rev Eukaryot Gene Expr. 1993;3(1):31-46.
Osteogenic growth polypeptides such as the osteogenic growth peptide (OGP), fragments of the parathyroid hormone (PTH), and insulin-like growth factors (IGF) regulate bone cell activity in vitro and may affect in vivo osteoblastic functions in an autocrine, paracrine, or endocrine manner. Several growth polypeptides capable of regulating osteogenesis circulate in the blood in an inactive form, complexed to parent molecules or binding proteins. During postablation bone marrow regeneration these factors may be activated, released from the blood clot, and together with locally produced polypeptides mediate the initial intramedullary/systemic osteogenic phase of this process. Then osteogenic growth polypeptides expressed by osteoblasts and other stromal cells have the potential to promote the second phase of regeneration that consists of osteoclastogenesis, resorption of the transient intramedullary bone, and hemopoiesis. This is probably an indirect effect inasmuch as these polypeptides can regulate the stromal cell expression of hemopoietic factors such as macrophage colony stimulating factor (M-CSF), granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin 6 (IL-6), and the stem cell factor (SCF). The postablation marrow regeneration model is suitable for studying the expression and activity of osteogenic growth polypeptides and already has been used to assess the effect of aging on these parameters. Clinically, the osteogenic growth polypeptides and marrow regeneration have a potential role in osteoporosis therapy, implant and corrective bone surgery, and bone marrow transplantation.
成骨生长多肽，如成骨生长肽（OGP）、甲状旁腺激素（PTH）片段和胰岛素样生长因子（IGF），在体外调节骨细胞活性，并可能以自分泌、旁分泌或内分泌方式影响体内成骨细胞功能。几种能够调节骨生成的生长多肽以无活性形式在血液中循环，与母体分子或结合蛋白结合。在骨髓消融后的再生过程中，这些因子可能被激活，从血凝块中释放出来，并与局部产生的多肽一起介导该过程最初的髓内/全身成骨阶段。然后，成骨细胞和其他基质细胞表达的成骨生长多肽有可能促进再生的第二阶段，该阶段包括破骨细胞生成、短暂髓内骨的吸收和造血。这可能是一种间接作用，因为这些多肽可以调节造血因子如巨噬细胞集落刺激因子（M-CSF）、粒细胞-巨噬细胞集落刺激因子（GM-CSF）、白细胞介素6（IL-6）和干细胞因子（SCF）的基质细胞表达。骨髓消融后再生模型适用于研究成骨生长多肽的表达和活性，并且已经用于评估衰老对这些参数的影响。临床上，成骨生长多肽和骨髓再生在骨质疏松症治疗、植入和矫正骨手术以及骨髓移植中具有潜在作用。
