Immunosciences Lab., Inc., Los Angeles, CA 90035, USA.
Evid Based Complement Alternat Med. 2011;2011:548086. doi: 10.1093/ecam/nep064. Epub 2011 Jun 16.
Abundant research has mapped the inflammatory pathways leading to autoimmunity and neuroinflammatory disorders. The latest T helper to be identified, Th17, through its proinflammatory cytokine IL-17, plays a pathogenic role in many inflammatory conditions. Today, healthcare providers have a wealth of anti-inflammatory agents from which to choose. On one hand, pharmaceutical companies market brand-name drugs direct to the public and physicians. Medical botanical knowledge, on the other hand, has been passed down from generation to generation. The demands for natural healing therapies have brought corresponding clinical and laboratory research studies to elucidate the medicinal properties of alternative practices. With a variety of options, it can be difficult to pinpoint the proper anti-inflammatory agent for each case presented. In this review, the authors highlight a vast array of anti-inflammatory medicaments ranging from drugs to vitamins and from botanicals to innate molecules. This compilation may serve as a guide for complimentary and alternative healthcare providers who need to target neuroinflammation driven by Th17 and its inflammatory cytokine IL-17. By understanding the mechanisms of anti-inflammatory agents, CAM practitioners can tailor therapeutic interventions to fit the needs of the patient, thereby providing faster relief from inflammatory complaints.
大量研究已经绘制出导致自身免疫和神经炎症性疾病的炎症途径。最新鉴定的辅助性 T 细胞 17（Th17）通过其促炎细胞因子白细胞介素-17（IL-17）在许多炎症性疾病中发挥致病作用。如今，医疗保健提供者有丰富的抗炎药物可供选择。一方面，制药公司直接向公众和医生推销品牌药物。另一方面，医学植物学知识代代相传。对自然疗法的需求带来了相应的临床和实验室研究，以阐明替代实践的药用特性。有多种选择，很难为每个提出的病例确定适当的抗炎药物。在这篇综述中，作者强调了大量的抗炎药物，从药物到维生素，从植物药到先天分子。这一汇编可以作为补充和替代医疗保健提供者的指南，他们需要针对 Th17 及其炎症细胞因子白细胞介素-17 驱动的神经炎症。通过了解抗炎药物的作用机制，CAM 从业者可以根据患者的需求调整治疗干预措施，从而更快地缓解炎症性投诉。
