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高分子量聚γ-谷氨酸的新生物学功能和应用。

New biological functions and applications of high-molecular-mass poly-gamma-glutamic acid.

机构信息

KRIBB, 52 Oun-dong, Yuseong-gu, Daejeon 305-806, Korea.

出版信息

Chem Biodivers. 2010 Jun;7(6):1555-62. doi: 10.1002/cbdv.200900283.

DOI:10.1002/cbdv.200900283
PMID:20564573
Abstract

Ultra-high-molecular-weight poly-gamma-glutamic acid (gamma-PGA) is a most promising biodegradable polymer that is produced by Bacillus subtilis (chungkookjang). Attractive properties of gamma-PGA are that it is water soluble, anionic, biodegradable, and edible. Development of gamma-PGA has pursued in terms of cosmetics/skin care, bone care, nanoparticle for drug delivery system, hydrogel, and so on. Very recently, our research has shown that gamma-PGA can be used as an immune-stimulating agent, especially at high molecular weight. This review presents the synthesis and production of high-molecular-weight gamma-PGA and its various applications in industrial fields.

摘要

超高相对分子质量聚γ-谷氨酸（γ-PGA）是一种很有前途的可生物降解聚合物，由枯草芽孢杆菌（纳豆）生产。γ-PGA 的诱人特性在于它水溶性、阴离子、可生物降解和可食用。γ-PGA 的开发一直追求在化妆品/护肤品、骨骼护理、药物输送系统的纳米粒子、水凝胶等领域的应用。最近，我们的研究表明γ-PGA 可用作免疫刺激剂，特别是在高分子量时。本文综述了高分子量γ-PGA 的合成和生产及其在工业领域的各种应用。

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