Huber S J, Bornstein R A, Rammohan K W, Christy J A, Chakeres D W, McGhee R B
Department of Neurology, University of Kansas Medical Center, Kansas City 66103.
J Neuropsychiatry Clin Neurosci. 1992 Spring;4(2):152-8. doi: 10.1176/jnp.4.2.152.
The authors examined whether specific neuropsychological abnormalities in multiple sclerosis (MS) are associated with focal lesion areas detected by MRI. Lesion area, regardless of distribution, correlated with performance on the vast majority of neuropsychological procedures. No significant difference appeared between groups with normal/mild and moderate overall cognitive impairment on any of the MRI measures. However, patients with severe cognitive impairment had greater lesion area, regardless of location, and had significant atrophy of the corpus callosum compared with the other two groups. These results suggest that severe atrophy of the corpus callosum reflects global disease and provides a relatively focal morphological marker of severe cognitive impairment in MS.
作者们研究了多发性硬化症（MS）中特定的神经心理学异常是否与MRI检测到的局灶性病变区域相关。病变区域，无论其分布如何，都与绝大多数神经心理学测试的表现相关。在任何MRI测量指标上，正常/轻度和中度整体认知障碍组之间均未出现显著差异。然而，与其他两组相比，严重认知障碍患者的病变区域更大，无论其位置如何，且胼胝体有明显萎缩。这些结果表明，胼胝体的严重萎缩反映了整体疾病情况，并为MS中严重认知障碍提供了一个相对局灶性的形态学标志物。
