Lazarus A
Temple University School of Medicine, Philadelphia, Pennsylvania.
J Neuropsychiatry Clin Neurosci. 1992 Spring;4(2):185-7. doi: 10.1176/jnp.4.2.185.
A case of neuroleptic malignant syndrome (NMS) is described in a congenitally brain-damaged deaf patient. The literature suggests that NMS in patients with organic brain syndrome is induced by a reduction of marginal stores of dopamine in the hypothalamus and basal ganglia resulting from dopamine-blocking activity of neuroleptics, even at conventionally low doses. Brain-damaged patients should be recognized as being at higher risk of developing NMS.
本文描述了一例患有先天性脑损伤的失聪患者发生抗精神病药恶性综合征（NMS）的病例。文献表明，患有器质性脑综合征的患者发生NMS是由于抗精神病药的多巴胺阻断活性导致下丘脑和基底神经节中多巴胺边缘储备减少所致，即使是常规低剂量用药也会如此。脑损伤患者应被视为发生NMS的高危人群。
