Adsersen Anne, Gauguin Bente, Gudiksen Lene, Jäger Anna K
Department of Medicinal Chemistry, The Danish University of Pharmaceutical sciences, 2 Universitetsparken, 2100 Copenhagen O, Denmark.
J Ethnopharmacol. 2006 Apr 6;104(3):418-22. doi: 10.1016/j.jep.2005.09.032. Epub 2005 Nov 8.
Aqueous and methanolic extracts of 11 plants, used in Danish folk medicine for improvement of memory and cognition, and 3 Corydalis species were tested for acetylcholinesterase inhibitory activity using the Ellman colorimetric method. Significant inhibitory activity in dose-dependent manner was observed for extracts of Corydalis cava, Corydalis intermedia, Corydalis solida ssp. laxa and Corydalis solida ssp. slivenensis. Extracts of Ruta graveolens, Lavandula angustifolia, Rosmarinus officinalis, Petroselinum crispum and Mentha spicata exhibited moderate inhibition of the enzyme, defined as more than 15% at 0.1 mg/ml.
对丹麦民间医学中用于改善记忆和认知的11种植物以及3种紫堇属植物的水提取物和甲醇提取物，采用埃尔曼比色法测试其乙酰胆碱酯酶抑制活性。观察到延胡索、中间紫堇、松弛紫堇亚种和斯利文紫堇亚种的提取物具有显著的剂量依赖性抑制活性。芸香、薰衣草、迷迭香、皱叶欧芹和留兰香的提取物对该酶表现出中度抑制作用，定义为在0.1毫克/毫升时抑制率超过15%。
