Kellett S C, Gawkrodger D J
Department of Clinical Psychology, Keresforth Centre, Barnsley S70 6RS, UK.
Eur J Dermatol. 2005 Nov-Dec;15(6):484-8.
The degree and manner to which isotretinoin affects the mental health of acne patients has not been extensively researched, despite reports of possible associations between isotretinoin and depression. In this study, 33 patients with acne were prescribed a standard 16-week treatment regime with isotretinoin. At the initiation of isotretinoin treatment, week 8 review and termination of treatment, patients completed validated measures of depression, hopelessness and self-rated dermatological severity and were also assessed dermatologically using an acne grading protocol. When the first phase of isotretinoin treatment (week 1 to week 8) was compared to the second phase (week 9 to week 16), patients reported significant improvements in the cognitive-affective features of depression during the first phase of treatment, but not during the second phase. Corresponding improvements in the somatic symptoms of depression and hopelessness were not found. The implications of the research are discussed in relation to methodological design issues in this area.
尽管有报告称异维A酸与抑郁症之间可能存在关联，但异维A酸对痤疮患者心理健康的影响程度和方式尚未得到广泛研究。在本研究中，33名痤疮患者接受了为期16周的异维A酸标准治疗方案。在异维A酸治疗开始时、第8周复查时和治疗结束时，患者完成了抑郁症、绝望感和自评皮肤病严重程度的有效测量，并且还使用痤疮分级方案进行了皮肤病学评估。当将异维A酸治疗的第一阶段（第1周至第8周）与第二阶段（第9周至第16周）进行比较时，患者报告在治疗的第一阶段抑郁症的认知情感特征有显著改善，但在第二阶段没有。未发现抑郁症和绝望感的躯体症状有相应改善。结合该领域的方法学设计问题对该研究的意义进行了讨论。
