Citrome Leslie
New York University School of Medicine, Department of Psychiatry, and Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
J Psychopharmacol. 2005 Nov;19(6 Suppl):84-93. doi: 10.1177/0269881105058375.
Metabolic syndrome is a constellation of clinical findings that identify individuals at higher than normal risk of developing diabetes mellitus or cardiovascular disease. There are two principal definitions, one emerging from the American National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, and the other from the World Health Organization. Both definitions share the common elements of abdominal obesity, hypertriglyceridaemia, low HDL-cholesterol, hypertension and abnormal glucose regulation. The syndrome is relatively common across continents, and also among those without marked obesity. It is even more common among patients with major mental health disorders such as schizophrenia. Metabolic syndrome can be used to assess risk for cardiovascular disorder and death, and is an alternative to Framingham Risk Calculations. C-reactive protein may play an additional role in risk prediction. Ongoing monitoring for all components of the metabolic syndrome is necessary. Individuals at high risk require multimodal interventions, including lifestyle interventions and targeted medications as appropriate.
代谢综合征是一组临床症状，用于识别患糖尿病或心血管疾病风险高于正常水平的个体。有两种主要定义，一种源自美国国家胆固醇教育计划成人高胆固醇检测、评估和治疗专家小组，另一种源自世界卫生组织。两种定义都有腹部肥胖、高甘油三酯血症、低高密度脂蛋白胆固醇、高血压和血糖调节异常这些共同要素。该综合征在各大洲都相对常见，在没有明显肥胖的人群中也很常见。在患有精神分裂症等严重精神疾病的患者中更为常见。代谢综合征可用于评估心血管疾病和死亡风险，是弗明汉风险计算的替代方法。C反应蛋白可能在风险预测中发挥额外作用。对代谢综合征的所有组成部分进行持续监测是必要的。高危个体需要多模式干预，包括生活方式干预和适当的靶向药物治疗。
