Bobichon H, Okiemi M G, Broglio C, Ploton D, Dufer J
Laboratoire de Biologie et GIBSA, UFR Pharmacie, Reims, France.
Biol Cell. 1992;74(3):287-97. doi: 10.1016/0248-4900(92)90040-8.
Ultrastructural changes associated with adriamycin (ADM) resistance have been investigated in the human K562 leukaemic cell line: sensitive K562 cells, a resistant subline cultured in the continuous presence of ADM and resistant cells without ADM Transmission electron microscopy (TEM) study revealed that K562-resistant cells displayed ultrastructural modifications of the cell surface, chromatin and nucleolus conformation. Alterations were not directly related to the presence of adriamycin as deprivated cells exhibited modificated characters through a slow progressive recovery phenomenon.
在人K562白血病细胞系中研究了与阿霉素（ADM）耐药相关的超微结构变化：敏感的K562细胞、在持续存在阿霉素的情况下培养的耐药亚系以及无阿霉素的耐药细胞。透射电子显微镜（TEM）研究显示，K562耐药细胞表现出细胞表面、染色质和核仁构象的超微结构改变。这些改变与阿霉素的存在没有直接关系，因为去除药物的细胞通过缓慢的渐进性恢复现象表现出改变的特征。
