Emery P, Bradley H, Arthur V, Tunn E, Waring R
Department of Rheumatology, University of Birmingham, Edgbaston.
Br J Rheumatol. 1992 Jul;31(7):449-51. doi: 10.1093/rheumatology/31.7.449.
A minority of individuals have an impaired ability to oxidize sulphur. An increased prevalence of this poor S-oxidation capacity has been observed in patients with established rheumatoid arthritis (RA). The role of this enzyme system in the development of disease was studied by testing the S-oxidation capacity of 54 patients with recent onset symmetrical poly-arthritis, who were followed up at 1 and 4 years. Those patients with persistent disease at 1 year had a prevalence of poor S-oxidation of 69%. At 4 years 74% of those with a diagnosis of RA were poor S-oxidizers compared to 31% of those who were asymptomatic (P less than 0.01). A defective ability to oxidize sulphur appears to predispose to persistent clinical disease.
少数个体氧化硫的能力受损。在确诊的类风湿性关节炎（RA）患者中，这种硫氧化能力差的情况更为普遍。通过检测54例近期发病的对称性多关节炎患者的硫氧化能力，研究了该酶系统在疾病发展中的作用，并对这些患者进行了1年和4年的随访。1年后仍患有持续性疾病的患者中，硫氧化能力差的患病率为69%。4年后，诊断为RA的患者中有74%硫氧化能力差，而无症状者中这一比例为31%（P<0.01）。硫氧化能力缺陷似乎易导致持续性临床疾病。
