Madhok R, Zoma A, Torley H I, Capell H A, Waring R, Hunter J A
Centre for Rheumatic Diseases, Royal Infirmary, Glasgow, Scotland.
Arthritis Rheum. 1990 Apr;33(4):574-7. doi: 10.1002/art.1780330416.
Penicillamine shows some structural similarities to carbocysteine. The ability to oxidize carbocysteine, i.e., the sulfoxidation status, shows a bimodal distribution in the general population. In this study, sulfoxidation status was determined in 50 of 60 rheumatoid arthritis patients receiving penicillamine. We found that poor sulfoxidation status, compared with good sulfoxidation status, was associated with a 3.9 times higher incidence of toxicity.
青霉胺与半胱氨酸有一些结构上的相似之处。氧化半胱氨酸的能力，即硫氧化状态，在普通人群中呈双峰分布。在本研究中，对60名接受青霉胺治疗的类风湿性关节炎患者中的50名进行了硫氧化状态测定。我们发现，与硫氧化状态良好相比，硫氧化状态不佳与毒性发生率高3.9倍相关。
