系统性红斑狼疮中的抗心磷脂抗体、溶血性贫血和血小板减少症。

Anticardiolipin antibodies, haemolytic anaemia and thrombocytopenia in systemic lupus erythematosus.

作者信息

Fong K Y, Loizou S, Boey M L, Walport M J

机构信息

Medical Unit IV, Tan Tock Seng Hospital, Singapore.

出版信息

Br J Rheumatol. 1992 Jul;31(7):453-5. doi: 10.1093/rheumatology/31.7.453.

DOI:10.1093/rheumatology/31.7.453

PMID:1628167

Abstract

Anticardiolipin antibody (ACA) levels were determined in 17 Asian female SLE patients with autoimmune haemolytic anaemia (AIHA) and 29 Asian female SLE inpatients without AIHA (control patients). Both IgG and IgM isotypes were measured by ELISA. Elevated IgM APA titres (greater than 5 SD of normal health controls) were seen in 11 (64.7%) of 17 AIHA patients and six (20.7%) of 29 control patients (P less than 0.01). There was no significant difference in IgG ACA titres between the two groups. Thrombocytopenia was present in 11 (64.7%) of the AIHA patients and nine (31%) of the control patients (P less than 0.05). None of the control SLE patients with thrombocytopenia had raised IgM ACA levels and only one had an elevated IgG ACA titre. Autoimmune haemolytic anaemia occurring in the context of SLE frequently associated with the concomitant presence of thrombocytopenia (Evan's syndrome) and with the presence of ACA.

摘要

测定了17例患有自身免疫性溶血性贫血（AIHA）的亚洲女性系统性红斑狼疮（SLE）患者和29例无AIHA的亚洲女性SLE住院患者（对照患者）的抗心磷脂抗体（ACA）水平。通过酶联免疫吸附测定法检测IgG和IgM两种亚型。17例AIHA患者中有11例（64.7%）和29例对照患者中有6例（20.7%）的IgM型抗磷脂抗体（APA）滴度升高（高于正常健康对照的5个标准差）（P<0.01）。两组之间的IgG ACA滴度无显著差异。AIHA患者中有11例（64.7%）存在血小板减少，对照患者中有9例（31%）存在血小板减少（P<0.05）。血小板减少的对照SLE患者中，没有一例IgM ACA水平升高，只有一例IgG ACA滴度升高。SLE患者发生的自身免疫性溶血性贫血常与血小板减少（伊文氏综合征）和ACA的存在同时出现。