抗心磷脂抗体、网状青斑与系统性红斑狼疮中的主要脑血管及肾脏疾病
Anticardiolipin antibodies, livedo reticularis, and major cerebrovascular and renal disease in systemic lupus erythematosus.
作者信息
McHugh N J, Maymo J, Skinner R P, James I, Maddison P J
机构信息
Royal National Hospital for Rheumatic Diseases, Bath, England.
出版信息
Ann Rheum Dis. 1988 Feb;47(2):110-5. doi: 10.1136/ard.47.2.110.
Abstract
Increased levels of IgG anticardiolipin antibodies (ACA) were found in 23 of 98 patients (23%) with systemic lupus erythematosus. Increased levels of IgM ACA were found less frequently (5%). All four patients with major cerebrovascular events had increased IgG ACA, including the two with highest levels, both of whom were men. Six of nine patients with livedo reticularis had increased IgG ACA. In turn, this clinical feature was associated with cerebrovascular disease in two and renal disease in another six. IgG ACA were not associated with other thromboembolic events, thrombocytopenia, serum IgG, or autoantibodies to Ro(SSA), La(SSB), U1RNP, Sm, or double or single stranded DNA.
摘要
在98例系统性红斑狼疮患者中，23例（23%）检测到抗心磷脂抗体（ACA）IgG水平升高。IgM ACA水平升高的情况较少见（5%）。所有4例发生重大脑血管事件的患者IgG ACA均升高，其中2例水平最高，且均为男性。9例网状青斑患者中有6例IgG ACA升高。反过来，这一临床特征在2例患者中与脑血管疾病相关，在另外6例患者中与肾脏疾病相关。IgG ACA与其他血栓栓塞事件、血小板减少、血清IgG或抗Ro(SSA)、La(SSB)、U1RNP、Sm或双链或单链DNA自身抗体无关。
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