系统性红斑狼疮及相关自身免疫性疾病中的血小板减少症：与抗心磷脂抗体的关联。

Thrombocytopenia in SLE and related autoimmune disorders: association with anticardiolipin antibody.

作者信息

Harris E N, Asherson R A, Gharavi A E, Morgan S H, Derue G, Hughes G R

出版信息

Br J Haematol. 1985 Feb;59(2):227-30. doi: 10.1111/j.1365-2141.1985.tb02988.x.

DOI:10.1111/j.1365-2141.1985.tb02988.x

Abstract

Anticardiolipin antibody levels were determined in 116 patients with systemic lupus erythematosus and related autoimmune disorders. Forty-three of these patients had a history of thrombocytopenia--36 of whom had SLE, three primary Sjögren's syndrome, two rheumatoid arthritis and two mixed connective tissue disease. IgG anticardiolipin antibody levels were raised in 31 (72%) of the 43 patients and IgM anticardiolipin antibody levels were raised in 19 (44%). There was a strong statistical correlation between thrombocytopenia and raised anticardiolipin antibody levels of both the IgG (P less than 0.001) and IgM (P less than 0.01) immunoglobulin classes. Of the 20 patients with the highest IgG anticardiolipin antibody levels 16 had a history of thrombocytopenia. We suggest that anticardiolipin antibodies may play a direct role in mediating platelet destruction in autoimmune disorders.

摘要

测定了116例系统性红斑狼疮及相关自身免疫性疾病患者的抗心磷脂抗体水平。其中43例患者有血小板减少病史，其中36例患有系统性红斑狼疮，3例患有原发性干燥综合征，2例患有类风湿关节炎，2例患有混合性结缔组织病。43例患者中有31例（72%）的IgG抗心磷脂抗体水平升高，19例（44%）的IgM抗心磷脂抗体水平升高。血小板减少与IgG（P<0.001）和IgM（P<0.01）免疫球蛋白类抗心磷脂抗体水平升高之间存在很强的统计学相关性。在IgG抗心磷脂抗体水平最高的20例患者中，16例有血小板减少病史。我们认为抗心磷脂抗体可能在自身免疫性疾病中介导血小板破坏中起直接作用。