Kim Sang Hyuk, Lee Hyun, Kim Bo-Guen, Kim Sang-Heon, Sohn Jang Won, Yoon Ho Joo, Jang Seung Hun, Park Dong Won
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Dongguk University Gyeongju Hospital, Dongguk University College of Medicine, Gyeongju 38066, Republic of Korea.
Division of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang University College of Medicine, Seoul 04763, Republic of Korea.
Cancers (Basel). 2024 May 30;16(11):2063. doi: 10.3390/cancers16112063.
Comprehensive analyses of the association between a family history of lung cancer and lung cancer risk are limited, especially in the Korean population. We used baseline data from the Korean Genome and Epidemiology Study, conducted between 2001 and 2013. This study enrolled 198,980 individuals. Lung cancer diagnoses and family histories were determined using questionnaires. Multivariable logistic regression analysis was performed to evaluate the effect of family history on the risk of lung cancer. Of 198,980 individuals, 6296 (3.2%) and 140 (0.1%) had a family history of lung cancer and lung cancer, respectively. Individuals with a family history of lung cancer in first-degree relatives (FDRs) had a higher risk of lung cancer development than those without (adjusted odds ratio [aOR] = 2.28, 95% confidence interval [CI] = 1.11-4.66). This was more pronounced in young individuals (<60 years) who had affected relatives diagnosed with lung cancer before the age of 60 years (aOR = 3.77, 95% CI = 1.19-11.88). In subgroup analyses, this association was more evident in women, never smokers, and young individuals. A family history of lung cancer, especially in FDRs, is a significant risk factor for lung cancer development in Korea.
关于肺癌家族史与肺癌风险之间关联的综合分析有限，尤其是在韩国人群中。我们使用了2001年至2013年期间进行的韩国基因组与流行病学研究的基线数据。该研究招募了198,980名个体。肺癌诊断和家族史通过问卷确定。进行多变量逻辑回归分析以评估家族史对肺癌风险的影响。在198,980名个体中，分别有6296名（3.2%）和140名（0.1%）有肺癌家族史和患肺癌。一级亲属（FDRs）中有肺癌家族史的个体患肺癌的风险高于无家族史者（调整后的优势比[aOR]=2.28，95%置信区间[CI]=1.11 - 4.66）。这在亲属在60岁之前被诊断为肺癌的年轻个体（<60岁）中更为明显（aOR = 3.77，95% CI = 1.19 - 11.88）。在亚组分析中，这种关联在女性、从不吸烟者和年轻个体中更为明显。肺癌家族史，尤其是在一级亲属中，是韩国肺癌发生的一个重要风险因素。
