Hanaoka Takaomi, Sone Shusuke, Ino Hitoshi, Takayama Fumiyoshi, Sato Toshiyuki, Kanaya Hiroshi, Ogata Hiroyuki
Department of Surgery, JA. Azumi General Hospital, Nagano, Japan.
J Thorac Imaging. 2005 Nov;20(4):288-90. doi: 10.1097/01.rti.0000167090.21554.55.
To our knowledge, no report exists of a subcentimeter size large cell neuroendocrine carcinoma (LCNEC) of the lung. A 75-year-old man participating in a low-dose CT screening program for lung cancer was found incidentally to have a partly-solid nodule in the right upper lung. After treatment with antibiotics, a repeat CT showed resolution of the nodule, but a new solid nodule measuring 9 x 9 mm was detected in the left lower lobe. The lesion showed marked enhancement on dynamic contrast-enhanced MRI. Video-assisted thoracic surgery and frozen section biopsy was suggestive of malignant lesion, resulting in extension of surgery to lobectomy with nodal dissection. The final diagnosis was stage IA-LCNEC. The estimated volume doubling time of the tumor was 30.1 days. These aggressive tumors may rarely have doubling times that overlap with benign processes.
据我们所知，尚无关于肺亚厘米大小大细胞神经内分泌癌（LCNEC）的报道。一名75岁男性参加肺癌低剂量CT筛查项目时，偶然发现右上肺有一个部分实性结节。抗生素治疗后，复查CT显示结节消散，但左下叶发现一个新的9×9mm实性结节。该病变在动态对比增强MRI上显示明显强化。电视辅助胸腔镜手术及冰冻切片活检提示为恶性病变，遂扩大手术范围行肺叶切除加淋巴结清扫。最终诊断为IA期LCNEC。肿瘤的估计体积倍增时间为30.1天。这些侵袭性肿瘤的倍增时间可能很少与良性病变重叠。
