Akata Soichi, Okada Shinya, Maeda Junichi, Park Jinho, Yoshimura Mana, Saito Kazuhiro, Kakizaki Dai, Abe Kimihiko, Kato Harubumi
Department of Radiology, Tokyo Medical University, Tokyo 160-0023, Japan.
Clin Imaging. 2007 Nov-Dec;31(6):379-84. doi: 10.1016/j.clinimag.2007.04.027.
The purpose of our study was to describe the computed tomography (CT) findings of large cell neuroendocrine carcinoma (LCNEC) and to correlate radiological and pathological findings. We reviewed the CT findings of 36 patients [including the high-resolution computed tomography (HRCT) findings of 29 patients] with resected LCNEC specimens. There were 33 men (92%), and 30 patients had a smoking history (83%). Only one case was of the central type. Mediastinal or hilar lymphadenopathy was seen in 12 (33%), but only one showed bulky lymphadenopathy. The HRCT findings of LCNEC consisted of irregular margins (66%), surrounding emphysema (41%), notching (38%), calcifications (21%), and pleural indentation (24%). Our study indicates that the CT image of LCNEC generally shows a peripherally located, expansively growing, irregularly margined pulmonary mass, with or without calcification, and without bulky lymphadenopathy. While the CT image of LCNEC resembles that of squamous cell carcinoma, cavitation is infrequent. LCNEC cannot be differentiated from poorly differentiated adenocarcinoma or atypical carcinoid on the basis of CT findings.
我们研究的目的是描述大细胞神经内分泌癌（LCNEC）的计算机断层扫描（CT）表现，并将影像学和病理学表现相关联。我们回顾了36例经手术切除的LCNEC标本患者的CT表现[包括29例患者的高分辨率计算机断层扫描（HRCT）表现]。患者中有33名男性（92%），30例有吸烟史（83%）。仅1例为中央型。12例（33%）可见纵隔或肺门淋巴结肿大，但仅1例表现为明显的淋巴结肿大。LCNEC的HRCT表现包括边缘不规则（66%）、周围肺气肿（41%）、切迹（38%）、钙化（21%）和胸膜凹陷（24%）。我们的研究表明，LCNEC的CT图像通常显示为位于周边、呈膨胀性生长、边缘不规则的肺部肿块，有或无钙化，且无明显的淋巴结肿大。虽然LCNEC的CT图像与鳞状细胞癌相似，但空洞形成不常见。基于CT表现无法将LCNEC与低分化腺癌或非典型类癌相鉴别。
