JA Nagano Azumi General Hospital, Ikeda, Nagano, Japan.
Eur Radiol. 2012 Jan;22(1):104-19. doi: 10.1007/s00330-011-2241-0. Epub 2011 Aug 17.
To retrospectively assess the utility of semi-automated measurements by stratification of CT values of tumour size, CT value and doubling time (DT) using thin-section computed tomography (CT) images. The post-surgical outcomes of favourable and problematic tumours (more advanced p stage than IA, post-surgical recurrence or mortality from lung cancer) were compared using the measured values. The computed DTs were compared with manually measured values.
The study subjects comprised 85 patients (aged 33-80 years, 48 women, 37 men), followed-up for more than 5 years postoperatively, with 89 lung lesions, including 17 atypical adenomatous hyperplasias and 72 lung cancers. DTs were determined in 45 lesions.
For problematic lesions, whole tumour diameter and density were >18 mm and >-400 HU, respectively. The respective values for the tumour core (with CT values of -350 to 150 HU) were >15 mm and >-70 HU. Analysis of tumour core DTs showed interval tumour progression even if little progress was seen by standard tumour volume DT (TVDT).
Software-based volumetric measurements by stratification of CT values provide valuable information on tumour core and help estimate tumour aggressiveness and interval tumour progression better than standard manually measured 2D-VDTs.
通过对肿瘤大小的 CT 值、CT 值和倍增时间（DT）进行分层，对薄层计算机断层扫描（CT）图像进行半自动测量，回顾性评估其应用价值。使用测量值比较术后结果良好和有问题的肿瘤（比 IA 期更晚期的 p 分期、术后复发或肺癌死亡）。比较计算的 DT 与手动测量值。
研究对象包括 85 名患者（年龄 33-80 岁，48 名女性，37 名男性），术后随访时间超过 5 年，共 89 个肺部病变，包括 17 个非典型腺瘤性增生和 72 个肺癌。在 45 个病变中确定了 DT。
对于有问题的病变，整个肿瘤直径和密度分别大于 18mm 和大于-400HU。肿瘤核心（CT 值为-350 至 150HU）的相应值分别大于 15mm 和大于-70HU。对肿瘤核心 DT 的分析表明，即使标准肿瘤体积 DT（TVDT）显示肿瘤进展不大，也存在间隔肿瘤进展。
基于软件的基于 CT 值分层的容积测量可提供有关肿瘤核心的有价值信息，并有助于更好地估计肿瘤侵袭性和间隔肿瘤进展，优于标准手动测量的 2D-VDT。
