在门静脉血栓形成的地方性流行区域，凝血酶原G20210A基因变异与特发性门静脉血栓形成无关。

Prothrombin G20210A gene variant is not associated with idiopathic portal vein thrombosis in an area endemic for portal vein thrombosis.

作者信息

Koshy Abraham, Jeyakumari Mary

机构信息

Department of Gastroenterology, Institute of Population Health and Clinical Research, St John's Medical College Hospital, Bangalore, India.

出版信息

Ann Hematol. 2006 Feb;85(2):126-8. doi: 10.1007/s00277-005-0020-1. Epub 2005 Nov 10.

DOI:10.1007/s00277-005-0020-1

PMID:16283309

Abstract

Prothrombin G20210A gene variant has been found in 0-23% of patients with portal vein thrombosis (PVT). This wide variation makes it difficult to assess the importance of prothrombin G20210A gene variant as a predisposing factor for PVT. In this study from South India, none of the patients with idiopathic PVT (0/38) or any of the controls (0/46) had prothrombin G20210A gene variant. Prothrombin G20210A gene variant does not contribute to the development of PVT in India.

摘要

在0%-23%的门静脉血栓形成（PVT）患者中发现了凝血酶原G20210A基因变异。这种广泛的差异使得难以评估凝血酶原G20210A基因变异作为PVT易感因素的重要性。在这项来自印度南部的研究中，特发性PVT患者（0/38）或任何对照组（0/46）均未出现凝血酶原G20210A基因变异。在印度，凝血酶原G20210A基因变异对PVT的发生没有影响。