门静脉血栓形成：肝硬化及恶性肿瘤相关的非肝硬化、非肿瘤性肝外门静脉阻塞的病因及临床结局
Portal vein thrombosis: etiology and clinical outcome of cirrhosis and malignancy-related non-cirrhotic, non-tumoral extrahepatic portal venous obstruction.
作者信息
Jain Pankaj, Nijhawan Sandeep
机构信息
Department of Gastroenterology, Sms Medical College, Jaipur, India.
出版信息
World J Gastroenterol. 2007 Oct 21;13(39):5288-9. doi: 10.3748/wjg.v13.i39.5288.
The etiology and pathogenesis of portal vein thrombosis are unclear. Portal venous thrombosis presentation differs in cirrhotic and tumor-related versus non-cirrhotic and non-tumoral extrahepatic portal venous obstruction (EHPVO). Non-cirrhotic and non-tumoral EHPVO patients are young and present with well tolerated bleeding. Cirrhosis and tumor-related portal vein thrombosis patients are older and have a grim prognosis. Among the 118 patients with portal vein thrombosis, 15.3% had cirrhosis, 42.4% had liver malignancy (primary or metastatic), 6% had pancreatitis (acute or chronic), 5% had hypercoagulable state and 31.3% had idiopathy, 12% had hypercoagulable state in the EHPVO group.
门静脉血栓形成的病因和发病机制尚不清楚。门静脉血栓形成在肝硬化和肿瘤相关与非肝硬化和非肿瘤性肝外门静脉阻塞（EHPVO）中的表现有所不同。非肝硬化和非肿瘤性EHPVO患者较为年轻，出血耐受性良好。肝硬化和肿瘤相关门静脉血栓形成患者年龄较大，预后较差。在118例门静脉血栓形成患者中，15.3%患有肝硬化，42.4%患有肝脏恶性肿瘤（原发性或转移性），6%患有胰腺炎（急性或慢性），5%处于高凝状态，31.3%病因不明，EHPVO组中有12%处于高凝状态。
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