Greer John J, Funk Gregory D, Ballanyi Klaus
University of Alberta, Department of Physiology, 513 HMRC, Edmonton, AB, Canada T6G 2S2.
J Physiol. 2006 Feb 1;570(Pt 3):437-44. doi: 10.1113/jphysiol.2005.097238. Epub 2005 Nov 10.
By birth, the regulatory neural network responsible for respiratory control is capable of generating robust rhythm-driving ventilation that can adjust to homeostatic needs. The advent of in vitro models isolated from prenatal rodents has significantly advanced our understanding of these processes. In this topical review, we examine the development of medullary respiratory rhythm-generating centres and phrenic motoneurone-diaphragm properties during the prenatal period.
从出生起,负责呼吸控制的调节神经网络就能够产生强大的节律驱动通气,以适应体内平衡的需求。从产前啮齿动物分离出的体外模型的出现,显著推进了我们对这些过程的理解。在这篇专题综述中,我们研究了产前时期延髓呼吸节律产生中枢和膈运动神经元 - 膈肌特性的发育情况。