Horenblas S, Kroon B K
Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis, afd. Urologie, Plesmanlaan 121, 1066 CX Amsterdam.
Ned Tijdschr Geneeskd. 2005 Oct 29;149(44):2450-3.
The incidence of penile cancer is low in men who have been circumcised at infancy. It is unknown whether a causative relationship exists between circumcision and the substantially reduced incidence of penile cancer. A normal foreskin has no known aetiological role in the development of penile cancer. A narrow, non-retractable foreskin predisposes the patient to infection and contributes to the development of penile cancer, together with the known risk factors of smoking and human papillomavirus infection. Circumcision represents a complex of social and behavioural factors. Analyses have not taken all of these factors into consideration. It is unlikely that circumcision itself protects against the development of penile cancer.
在婴儿期接受包皮环切术的男性中,阴茎癌的发病率较低。目前尚不清楚包皮环切术与阴茎癌发病率大幅降低之间是否存在因果关系。正常的包皮在阴茎癌的发生发展中尚无已知的病因学作用。狭窄、不能上翻的包皮使患者易发生感染,并与吸烟和人乳头瘤病毒感染等已知危险因素一起,促使阴茎癌的发生。包皮环切术代表了一系列社会和行为因素。分析并未将所有这些因素都考虑在内。包皮环切术本身不太可能预防阴茎癌的发生。