Department of Viruses, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, 2100 Copenhagen, Denmark.
Cancer Causes Control. 2012 Feb;23(2):273-80. doi: 10.1007/s10552-011-9876-7. Epub 2011 Nov 19.
To assess the trends in incidence of penile cancer during 1978-2008 and high-grade penile intraepithelial neoplasia (PIN2/3) during 1998-2008 in Denmark.
Using two nationwide registries, we estimated age- and period-specific incidence rates. Log-linear Poisson regression analysis was used to estimate average annual percentage change (AAPC) and 95% confidence intervals (CI).
We identified 1,488 men with penile cancer and 285 men with PIN2/3. The incidence of penile cancer increased from 1.0 to 1.3 per 100,000 men-years in 1978-1979 to 2006-2008; this represented an AAPC of 0.8% (95% CI: 0.17-1.37). Squamous cell carcinoma (SCC) was the most common histological type (91.7%). The median age at diagnosis was 67 years, and the age-specific incidence rate of penile SCC increased with increasing age. The incidence rate of PIN2/3 increased significantly (0.5 to 0.9 per 100,000 men-years) in 1998-1999 to 2006-2008, and this represented an AAPC of 7.1% (95% CI: 3.30-11.05).
The incidence of penile cancer increased in 1978-2008 in Denmark, and the same applied to PIN2/3 in 1998-2008. A high prevalence of human papillomavirus (HPV) and a low circumcision rate in Denmark may partly explain our results.
评估丹麦 1978-2008 年期间阴茎癌的发病趋势，以及 1998-2008 年期间高级别阴茎上皮内瘤变（PIN2/3）的发病趋势。
利用两个全国性登记处，我们估计了年龄和时期特异性发病率。对数线性泊松回归分析用于估计平均年百分比变化（AAPC）和 95%置信区间（CI）。
我们发现 1488 名患有阴茎癌的男性和 285 名患有 PIN2/3 的男性。1978-1979 年至 2006-2008 年期间，阴茎癌的发病率从每 100000 人年 1.0 例上升至 1.3 例；这代表 AAPC 为 0.8%（95%CI：0.17-1.37）。最常见的组织学类型是鳞状细胞癌（SCC）（91.7%）。诊断时的中位年龄为 67 岁，年龄特异性阴茎 SCC 发病率随年龄增长而增加。1998-1999 年至 2006-2008 年期间，PIN2/3 的发病率显著增加（每 100000 人年 0.5 例至 0.9 例），这代表 AAPC 为 7.1%（95%CI：3.30-11.05）。
丹麦 1978-2008 年期间阴茎癌的发病率上升，PIN2/3 在 1998-2008 年期间也同样上升。HPV 高流行率和丹麦低割礼率可能部分解释了我们的结果。
