高度稳定的非离子表面活性剂囊泡的制备及其对药物的助溶作用。
Preparation of a highly stable niosome and its hydrotrope-solubilization action to drugs.
作者信息
Liu Tianqing, Guo Rong
机构信息
School of Chemistry and Chemical Engineering, Nanjing University, Jinagsu 210093, PR China.
出版信息
Langmuir. 2005 Nov 22;21(24):11034-9. doi: 10.1021/la051868b.
Highly stable niosomes are prepared and investigated in Tween80/PEG6000/Span80/H2O system. The mean radius of the niosomes is 0.15-0.2 microm. The contents of PEG6000 and Span80 and the system temperature affect the size and the stability of the niosome. A certain Span80 can remarkably improve the stability. The niosome is provided distinctly with the hydrotrope-solubilization action to the hydrophilic drug and hydrophobic drug, which affects the niosome membrane. The mechanism of the effects of PEG6000 and Span80 on the niosome is discussed in this paper.
在吐温80/聚乙二醇6000/司盘80/水体系中制备并研究了高度稳定的非离子表面活性剂囊泡。非离子表面活性剂囊泡的平均半径为0.15 - 0.2微米。聚乙二醇6000和司盘80的含量以及体系温度会影响非离子表面活性剂囊泡的大小和稳定性。一定量的司盘80能显著提高稳定性。非离子表面活性剂囊泡对亲水性药物和疏水性药物具有明显的助溶增溶作用，这会影响非离子表面活性剂囊泡膜。本文讨论了聚乙二醇6000和司盘80对非离子表面活性剂囊泡影响的作用机制。
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