Dinarello Charles A
University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
Immunity. 2005 Nov;23(5):461-2. doi: 10.1016/j.immuni.2005.10.004.
Activation of ST2, an orphan member of the IL-1 receptor family for 16 years, drives T helper type 2 (T(H)2) responses. The cytokine IL-33 is the specific ligand for ST2. IL-33 recapitulates much of the existing data that ST2 promotes T(H)2-type responses. The caspase-1 processing of precursor IL-33 provides a therapeutic target to control allergic diseases.
ST2是白细胞介素-1受体家族中一个长达16年的孤儿成员，其激活可驱动2型辅助性T细胞（Th2）反应。细胞因子白细胞介素-33（IL-33）是ST2的特异性配体。IL-33概括了许多关于ST2促进Th2型反应的现有数据。前体IL-33的半胱天冬酶-1加工提供了一个控制过敏性疾病的治疗靶点。
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