一种独立于Toll样受体（TLR）的半胱天冬酶-1炎性小体信号。
A signal for the caspase-1 inflammasome free of TLR.
作者信息
Dinarello Charles A
机构信息
Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue B168, Denver, CO 80262, USA.
出版信息
Immunity. 2007 Apr;26(4):383-5. doi: 10.1016/j.immuni.2007.04.005.
PMID:17459804
Abstract
Secretion of the proinflammatory cytokine IL-1beta requires caspase-1 and Toll-like receptor (TLR) signaling. However, Kanneganti et al. (2007) find that bacteria can use pore-forming mechanisms to activate caspase-1 for the production of IL-1beta precursor independently of TLRs.
摘要
促炎细胞因子白细胞介素-1β（IL-1β）的分泌需要半胱天冬酶-1和Toll样受体（TLR）信号传导。然而，坎内甘蒂等人（2007年）发现，细菌可以利用成孔机制激活半胱天冬酶-1，以独立于TLR产生IL-1β前体。
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