Department of Clinical Nutrition, Guangzhou Institute of Disease-Oriented Nutritional Research, Guangzhou Red Cross Hospital of Jinan University, Guangzhou 510220, China.
Department of Preventive Medicine, School of Medicine, Yanbian University, Yanji 133002, China.
Exp Biol Med (Maywood). 2023 Nov;248(22):2167-2174. doi: 10.1177/15353702231198075. Epub 2023 Oct 12.
Interleukin-33 (IL-33) is a member of the IL-1 cytokine family and is believed to play important roles in different diseases by binding to its specific receptor suppression of tumorigenicity 2 (ST2). In the heart, IL-33 is expressed in different cells including cardiomyocytes, fibroblasts, endothelium, and epithelium. Although many studies have been devoted to investigating the effects of IL-33 on heart diseases, its roles in myocardial injuries remain obscure, and thus further studies are mandatory to unravel the underlying molecular mechanisms. We highlighted the current knowledge of the molecular and cellular characteristics of IL-33 and then summarized its major roles in different myocardial injuries, mainly focusing on infection, heart transplantation, coronary atherosclerosis, myocardial infarction, and diabetic cardiomyopathy. This narrative review will summarize current understanding and insights regarding the implications of IL-33 in cardiac diseases and its diagnostic and therapeutic potential for cardiac disease management.
白细胞介素 33（IL-33）是白细胞介素 1 细胞因子家族的一员，通过与其特异性受体抑制肿瘤发生 2（ST2）结合，被认为在不同疾病中发挥重要作用。在心脏中，IL-33在不同的细胞中表达，包括心肌细胞、成纤维细胞、内皮细胞和上皮细胞。尽管许多研究致力于研究 IL-33 对心脏病的影响，但它在心肌损伤中的作用仍不清楚，因此需要进一步的研究来揭示潜在的分子机制。我们强调了 IL-33 的分子和细胞特征的最新知识，然后总结了它在不同心肌损伤中的主要作用，主要集中在感染、心脏移植、冠状动脉粥样硬化、心肌梗死和糖尿病心肌病上。本综述将总结目前对 IL-33 在心脏疾病中的意义及其在心脏疾病管理中的诊断和治疗潜力的理解和见解。
