Lakoski Susan G, Cushman Mary, Palmas Walter, Blumenthal Roger, D'Agostino Ralph B, Herrington David M
Department of Internal Medicine/Cardiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
J Am Coll Cardiol. 2005 Nov 15;46(10):1869-74. doi: 10.1016/j.jacc.2005.07.050. Epub 2005 Oct 24.
The goal of this study was to determine the relationship between resting blood pressure (BP) and C-reactive protein (CRP) in a multi-ethnic cohort of men and women from the Multi-Ethnic Study of Atherosclerosis (MESA).
Several investigators have observed elevated levels of CRP in individuals with hypertension. Hypertension prevalence varies considerably across ethnic groups. Important questions remain regarding whether the relationship between hypertension and CRP is similar across ethnic and gender subgroups.
The MESA participants had CRP levels determined at the baseline clinical examination (N = 6,814). Hypertension, treated as a dichotomous variable (yes/no), was defined as a systolic or diastolic BP > or =140/90 mm Hg or a self-reported history of hypertension and use of antihypertensive medications.
The geometric mean CRP in hypertensive participants was 2.3 +/- 0.07 mg/l compared with 1.6 +/- 0.07 mg/l among normotensive participants (p < 0.0001). The relative difference in CRP levels in hypertensives compared with normotensives was similar regardless of gender (13% in men and 13% in women). Ethnic comparisons showed that Chinese participants had the lowest CRP concentration but the largest difference in CRP by hypertension status (24%). Caucasians and African Americans had 10% to 15% higher CRP levels with hypertension, whereas Hispanics had no significant difference in CRP by hypertension status.
This study confirms the existence of an independent association between hypertension and inflammation in both men and women. Ethnic group differences were evident, with the strongest association observed in Chinese participants and no difference in CRP levels by hypertension status in Hispanics.
本研究的目的是在动脉粥样硬化多族裔研究（MESA）的多族裔男性和女性队列中确定静息血压（BP）与C反应蛋白（CRP）之间的关系。
几位研究者观察到高血压患者的CRP水平升高。高血压患病率在不同种族群体中差异很大。关于高血压与CRP之间的关系在不同种族和性别亚组中是否相似，仍存在重要问题。
MESA参与者在基线临床检查时测定了CRP水平（N = 6814）。高血压作为二分变量（是/否），定义为收缩压或舒张压≥140/90 mmHg或有自我报告的高血压病史并使用抗高血压药物。
高血压参与者的CRP几何平均值为2.3±0.07 mg/l，而血压正常参与者为1.6±0.07 mg/l（p < 0.0001）。无论性别如何，高血压患者与血压正常者相比，CRP水平的相对差异相似（男性为13%，女性为13%）。种族比较显示，中国参与者的CRP浓度最低，但高血压状态导致的CRP差异最大（24%）。白人和非裔美国人高血压患者的CRP水平高10%至15%，而西班牙裔高血压状态下的CRP无显著差异。
本研究证实了高血压与炎症在男性和女性中均存在独立关联。种族差异明显，中国参与者的关联最强，西班牙裔高血压状态下的CRP水平无差异。
