Boyle Peter
International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex08, France.
Breast. 2005 Dec;14(6):429-38. doi: 10.1016/j.breast.2005.10.001.
Breast cancer represents 10% of the global cancer burden and there is no population, or population sub-group, which has yet been identified to be at a truly low risk of developing the disease. Mortality rates have been steadily growing for nearly a century in many countries and it is only during the past decade that there have been signs of a sustainable decrease in mortality rates in a number of western-lifestyle countries. This represents considerable progress in breast cancer control and, although different factors contribute to different degrees in different countries, is mainly due to increased breast awareness, earlier detection and the delivery of the most appropriate therapy to women with the disease. The failure to prevent the incidence from continuing to rise represents to a great extent the failure to understand the precise mechanisms of breast carcinogenesis and the role of risk determinants whose alteration in society could lead to a reduced risk of developing the disease. The declines seen in mortality represent a considerable success, but there is no room for complacency until research can impact positively on reducing incidence.
乳腺癌占全球癌症负担的10%，目前尚未发现有任何人群或人群亚组患该疾病的风险极低。在许多国家，近一个世纪以来乳腺癌死亡率一直在稳步上升，直到过去十年，一些西方生活方式国家才出现死亡率持续下降的迹象。这在乳腺癌控制方面取得了相当大的进展，尽管不同因素在不同国家的作用程度不同，但主要归功于女性对乳房健康意识的提高、早期发现以及为患病女性提供最恰当的治疗。未能阻止发病率持续上升在很大程度上表明未能准确理解乳腺癌发生的确切机制以及风险决定因素的作用，而改变社会环境中的这些因素可能会降低患癌风险。死亡率的下降是一项巨大的成功，但在研究能够对降低发病率产生积极影响之前，仍不能自满。
