Langebrake C, Uhlenbrock S, Ritter J, Groll A H
Abteilung für Pädiatrische Hämatologie und Onkolgie, Medizinische Hochschule Hannover.
Klin Padiatr. 2005 Nov;217 Suppl 1:S165-74. doi: 10.1055/s-2005-872510.
Antimicrobial agents are among the most common therapeutics prescribed to children and adolescents with hematologic/oncologic disorders. Because of the polymorbid state of most patients, they are frequently administered concomitantly with other drugs, resulting in a considerable potential for drug interactions. While many of these interactions are of marginal clinical significance, others are associated with substantial risks of decreased therapeutic efficacy or increased drug toxicity. Prevention and recognition of drug interactions are therefore of vital importance to optimizing effective use of antimicrobials and enhancing patient outcome. Key to minimize drug interactions are a thorough understanding of the pharmacology of frequently used antimicrobial agents and a careful evaluation of risks and benefits of potentially interacting drugs. This article reviews mechanisms and clinical relevance of drug interactions of antimicrobial agents in the supportive care of children and adolescents with hematologic/oncologic disorders and provides strategies for their prevention.
抗菌药物是给患有血液学/肿瘤学疾病的儿童和青少年开的最常见的治疗药物之一。由于大多数患者存在多种疾病状态，它们经常与其他药物同时使用，从而导致药物相互作用的可能性相当大。虽然其中许多相互作用的临床意义不大，但其他相互作用则与治疗效果降低或药物毒性增加的重大风险相关。因此，预防和识别药物相互作用对于优化抗菌药物的有效使用和改善患者预后至关重要。尽量减少药物相互作用的关键是全面了解常用抗菌药物的药理学，并仔细评估潜在相互作用药物的风险和益处。本文综述了抗菌药物在患有血液学/肿瘤学疾病的儿童和青少年支持性治疗中药物相互作用的机制和临床相关性，并提供了预防策略。
