Horn J R, Hansten P D
Department of Pharmacy, School of Pharmacy, University of Washington, Seattle 98195, USA.
J Fam Pract. 1995 Jul;41(1):81-90.
Antibacterial drugs, such as quinolones, macrolides, rifampin, isoniazid, and trimethoprim-sulfamethoxazole, can interact with other drugs in a wide variety of clinically significant ways. They are frequently administered with other prescription and nonprescription medications. Antibacterial agents may interact by causing a change in the pharmacokinetics or pharmacodynamics of a second drug. In other cases, the antimicrobial may be affected by the action of another drug. Interactions involving antimicrobials often result from alterations in the absorption of the antimicrobial from the gastrointestinal tract or changes in the hepatic metabolism or renal elimination of the drugs concurrently administered. While certain classes of antibacterial drugs are known to interact with many other drugs, the interaction potential of most classes of antimicrobials is not uniform among members of the class. This diversity in interaction potential provides the clinician with an opportunity to avoid potential interactions by means of appropriate drug selection. An understanding of the common, clinically significant drug interactions involving antibacterial agents will enable the physician to avoid unnecessary adverse drug reactions.
抗菌药物，如喹诺酮类、大环内酯类、利福平、异烟肼和甲氧苄啶-磺胺甲恶唑，能以多种具有临床意义的方式与其他药物相互作用。它们经常与其他处方药和非处方药一起使用。抗菌药物可能通过引起第二种药物的药代动力学或药效学变化而相互作用。在其他情况下，抗菌药物可能会受到另一种药物作用的影响。涉及抗菌药物的相互作用通常是由于抗菌药物从胃肠道的吸收改变，或同时服用药物的肝脏代谢或肾脏排泄发生变化所致。虽然已知某些类别的抗菌药物会与许多其他药物相互作用，但大多数抗菌药物类别的相互作用潜力在该类别成员中并不一致。这种相互作用潜力的多样性为临床医生提供了一个通过适当选择药物来避免潜在相互作用的机会。了解涉及抗菌药物的常见、具有临床意义的药物相互作用将使医生能够避免不必要的药物不良反应。
