Adam Ishag, Salih Isam, Elbashir Mustafa Idris
New Halfa Teaching Hospital, Sudan.
Trans R Soc Trop Med Hyg. 2005 Oct;99(10):736-8. doi: 10.1016/j.trstmh.2005.05.005.
An observational clinical trial was conducted in New Halfa, eastern Sudan, in November and December 2003. Sixty-two patients with uncomplicated Plasmodium falciparum malaria were treated with oral quinine (10 mg/kg thrice daily for 7 d); 47 (76%) of these patients were followed-up to day 28, and 5 (10.6%) of them appeared to have late treatment failures. The parasitological failures were early R1 in two (4.3%) patients and late R1 in three (6.4%) patients. The reappearance of parasites in three of these five patients were true recrudescences rather than a re-infection, based on genetic evidence. The present results and those of earlier investigations indicate that the response to quinine in this area may be faltering.
2003年11月和12月，在苏丹东部的新哈尔法进行了一项观察性临床试验。62例无并发症的恶性疟原虫疟疾患者接受口服奎宁治疗（每日三次，每次10mg/kg，共7天）；其中47例（76%）患者随访至第28天，5例（10.6%）出现晚期治疗失败。寄生虫学失败的情况为：2例（4.3%）患者为早期R1，3例（6.4%）患者为晚期R1。根据基因证据，这5例患者中有3例寄生虫再现是真正的复发，而非再次感染。目前的结果和早期调查结果表明，该地区对奎宁的反应可能正在减弱。
