Packard A B, Lambert C
Division of Nuclear Medicine, Children's Hospital, Harvard Medical School, Boston, MA 02115.
Int J Rad Appl Instrum B. 1992 Apr;19(3):357-62. doi: 10.1016/0883-2897(92)90121-e.
The nitrosyl complexes pentachloronitrosylosmate(II), [OsCl5(NO)]2-, and hydroxytetranitronitrosylosmate(II), [Os(OH)(NO2)4(NO)]2-, were evaluated as parent species for use on the 191Os-191mIr generator in an attempt to increase the 191mIr yield of the generator by providing a direct route to a chemically stable 191mIr daughter. The uptake of the 191Os-labeled complexes by the inorganic ion-exchangers ZrO2, SnO2, PbS, MnO2 and Al2O3 and the organic resin AG MP-1 was measured and prototype generators were prepared using those exchangers that demonstrated greater than 90% uptake of the 191Os-labeled complexes. The 191mIr(III)-nitrosyl complexes produced subsequent to beta- decay of the 191Os-nitrosyl parent complexes were found to undergo secondary chemical reactions to form nitro (NO2-) complexes that were tightly retained on the ion exchanger limiting 191mIr yield to less than 5%.
评估了亚硝酰配合物五氯亚硝酰锇酸盐（II），[OsCl5(NO)]2-，以及羟基四硝基亚硝酰锇酸盐（II），[Os(OH)(NO2)4(NO)]2-，作为用于191Os-191mIr发生器的母体物种，试图通过提供一条通往化学稳定的191mIr子体的直接途径来提高发生器的191mIr产率。测量了无机离子交换剂ZrO2、SnO2、PbS、MnO2和Al2O3以及有机树脂AG MP-1对191Os标记配合物的摄取量，并使用那些对191Os标记配合物摄取量大于90%的交换剂制备了原型发生器。发现191Os-亚硝酰母体配合物β衰变后产生的191mIr(III)-亚硝酰配合物会发生二次化学反应，形成硝基（NO2-）配合物，这些配合物被紧紧保留在离子交换剂上，将191mIr产率限制在5%以下。
