Allison T G, Reger W E
Cardiac Center, Wheeling Hospital, West Virginia 26003.
J Appl Physiol (1985). 1992 Jun;72(6):2099-107. doi: 10.1152/jappl.1992.72.6.2099.
The goals of the study were to test the hypotheses that ethyl alcohol (ETOH) in low-to-moderate doses would alter thermo-regulation and/or disrupt the normal relationship between physiological and psychophysical indexes of heat stress during 40 degrees C water immersion and to characterize the cardiovascular response to the combined stimuli of heat, water immersion, and ETOH. Six healthy men underwent three trials of 21 min of immersion in water at 40.0 +/- 0.1 degrees C after consuming 0, 0.27, or 0.54 g ETOH/kg. Esophageal temperature (Tes) rose by approximately 1.0 degrees C during immersion for each trial. Per unit of Tes rise, changes during immersion in skin temperature, sweat rate, heart rate, systolic and diastolic blood pressure, and psychophysical assessments of comfort and overheating did not differ significantly by trial. Across trials, there was an apparent threshold for activation of thermoregulatory responses at an approximately 0.5 degrees C increase in Tes occurring after approximately 9 min of immersion. This threshold was identified psychophysically by increased ratings of overheating and decreased comfort. Above the threshold, there was an attenuation of the rate of increase of Tes. Cardiovascular stress was mild (rate-pressure product approximately 12,000) and not significantly increased by ETOH. Hypotension and tachycardia when subjects stood to exit the tub were observed. The data suggest that ETOH at the doses administered does not affect thermoregulatory, cardiovascular, or psychophysical indexes of heat stress during 40 degrees C water immersion.
低至中等剂量的乙醇（ETOH）会改变体温调节和/或破坏40℃水浸期间热应激的生理和心理物理指标之间的正常关系，并描述对热、水浸和ETOH联合刺激的心血管反应特征。六名健康男性在摄入0、0.27或0.54 g ETOH/kg后，进行了三次在40.0±0.1℃水中浸泡21分钟的试验。每次试验浸泡期间，食管温度（Tes）大约升高1.0℃。每升高单位Tes，各试验在浸泡期间皮肤温度、出汗率、心率、收缩压和舒张压以及舒适度和过热的心理物理评估的变化无显著差异。在各试验中，浸泡约9分钟后，Tes大约升高0.5℃时，存在激活体温调节反应的明显阈值。通过过热评分增加和舒适度降低，从心理物理角度确定了该阈值。高于该阈值时，Tes的上升速率减弱。心血管应激较轻（速率-压力乘积约为12,000），ETOH并未使其显著增加。观察到受试者从浴缸中站起来时出现低血压和心动过速。数据表明，所给予剂量的ETOH在40℃水浸期间不影响热应激的体温调节、心血管或心理物理指标。
