鲁比尼、杰里尔-林恩和尿病腮腺炎疫苗在亚洲人群中的比较疗效。 （注：原文中“Urabe”表述有误，推测可能是“Urabe AM9”，是腮腺炎疫苗的一种，按照正确的专业名称来理解，这里翻译可能会更准确，但仅依据所给文本翻译如上）
Comparative efficacy of Rubini, Jeryl-Lynn and Urabe mumps vaccine in an Asian population.
作者信息
Ong Gary, Goh Kee Tai, Ma Stefan, Chew Suok Kai
机构信息
Division of Epidemiology and Disease Control, Ministry of Health, College of Medicine Building, 16 College Road, Singapore 169854, Singapore.
出版信息
J Infect. 2005 Nov;51(4):294-8. doi: 10.1016/j.jinf.2004.10.001. Epub 2004 Nov 5.
OBJECTIVE
The comparative efficacy of the three mumps vaccine strains (Jeryl-Lynn, Urabe and Rubini) was conducted in an Asian population from data arising from an epidemiological investigation of seven institutional outbreaks of mumps in Singapore.
METHODS
Demographic information (gender, age, ethnic group), clinical presentation and vaccination history (date and place of mumps vaccination, type of mumps vaccine received) of all children who attended the six childcare centres and one primary school where outbreaks of 20 or more cases of mumps occurred in 1999 were collected. The attack rate of the unvaccinated group and the attack rates of the vaccine groups (for each vaccine strain) were determined and the vaccine efficacy of the three vaccines calculated.
RESULTS
The vaccine efficacy of the Jeryl-Lynn strain, Urabe strain and Rubini strain mumps vaccine were 80.7, 54.4 and -55.3%, respectively.
CONCLUSION
Rubini strain mumps vaccine conferred no protection and has since been deregistered in Singapore.
目的
根据新加坡七起机构性腮腺炎疫情的流行病学调查数据，对三种腮腺炎疫苗株（杰里尔-林恩株、尿病株和鲁比尼株）在亚洲人群中的比较疗效进行研究。
方法
收集了1999年在六家儿童保育中心和一所小学发生20例及以上腮腺炎疫情的所有儿童的人口统计学信息（性别、年龄、种族）、临床表现和疫苗接种史（腮腺炎疫苗接种日期和地点、接种的腮腺炎疫苗类型）。确定未接种疫苗组的发病率以及各疫苗组（每种疫苗株）的发病率，并计算三种疫苗的疫苗效力。
结果
杰里尔-林恩株、尿病株和鲁比尼株腮腺炎疫苗的疫苗效力分别为80.7%、54.4%和-55.3%。
结论
鲁比尼株腮腺炎疫苗没有提供保护作用，此后已在新加坡注销注册。
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