腮腺炎疫苗：当前挑战与未来前景
Mumps Vaccines: Current Challenges and Future Prospects.
作者信息
Almansour Iman
机构信息
Department of Epidemic Diseases Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
出版信息
Front Microbiol. 2020 Aug 20;11:1999. doi: 10.3389/fmicb.2020.01999. eCollection 2020.
Five decades have passed since the first mumps vaccine was licensed. Over this period, a resurgence of mumps infections has been recorded worldwide. Although global mumps infections have been controlled through vaccination, outbreaks are still on the rise, including in populations with high vaccination coverage. Several epidemiological studies suggest that this infectious virus continues to be a worldwide public health threat. The development and deployment of an improved, prophylactic mumps vaccine that provides long-lasting protection is indeed a priority. The purpose of this review is to provide an immuno-biological perspective on mumps vaccines. Here, we review the virology of mumps, licensed mumps vaccines, and the typical immune responses elicited following mumps vaccination. Furthermore, we discuss the limitations and challenges of the currently licensed mumps vaccines and provide strategies for the development of an improved mumps vaccine.
自首款腮腺炎疫苗获批以来，已经过去了五十年。在此期间，全球范围内都记录到腮腺炎感染有所抬头。尽管通过接种疫苗已控制了全球范围内的腮腺炎感染，但包括疫苗接种覆盖率高的人群在内，疫情仍在上升。多项流行病学研究表明，这种传染性病毒仍然是全球公共卫生威胁。开发并部署一种能提供持久保护的改良型预防性腮腺炎疫苗确实是当务之急。本综述的目的是从免疫生物学角度对腮腺炎疫苗进行阐述。在此，我们回顾腮腺炎的病毒学、已获批的腮腺炎疫苗以及接种腮腺炎疫苗后引发的典型免疫反应。此外，我们讨论了当前已获批的腮腺炎疫苗的局限性和挑战，并提供了开发改良型腮腺炎疫苗的策略。
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