Marson Charles M, Melling Robert C
Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H 0AJ, UK.
J Org Chem. 2005 Nov 25;70(24):9771-9. doi: 10.1021/jo0513414.
[reaction: see text] Asymmetric syntheses of enantiopure trans-3,4-difluoropyrrolidines have been prepared by the introduction of fluorine at both centers in a single operation; asymmetric epoxidations and additions to benzaldehyde were conducted using catalysts whose chirality depends on organofluorine asymmetry.
[反应：见正文] 通过在一次操作中在两个中心引入氟，制备了对映体纯的反式-3,4-二氟吡咯烷的不对称合成；使用手性取决于有机氟不对称性的催化剂进行不对称环氧化反应和对苯甲醛的加成反应。
