反式-3,4-二氟吡咯烷的对映选择性合成及其在催化不对称合成中的应用研究

Enantioselective syntheses of trans-3,4-difluoropyrrolidines and investigation of their applications in catalytic asymmetric synthesis.

作者信息

Marson Charles M, Melling Robert C

机构信息

Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H 0AJ, UK.

出版信息

J Org Chem. 2005 Nov 25;70(24):9771-9. doi: 10.1021/jo0513414.

DOI:10.1021/jo0513414

PMID:16292805

Abstract

[reaction: see text] Asymmetric syntheses of enantiopure trans-3,4-difluoropyrrolidines have been prepared by the introduction of fluorine at both centers in a single operation; asymmetric epoxidations and additions to benzaldehyde were conducted using catalysts whose chirality depends on organofluorine asymmetry.

摘要

[反应：见正文] 通过在一次操作中在两个中心引入氟，制备了对映体纯的反式-3,4-二氟吡咯烷的不对称合成；使用手性取决于有机氟不对称性的催化剂进行不对称环氧化反应和对苯甲醛的加成反应。