吡咯烷-硫脲作为双功能有机催化剂：环己酮与硝基烯烃的高对映选择性迈克尔加成反应
Pyrrolidine-thiourea as a bifunctional organocatalyst: highly enantioselective Michael addition of cyclohexanone to nitroolefins.
作者信息
Cao Chun-Li, Ye Meng-Chun, Sun Xiu-Li, Tang Yong
机构信息
The State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China.
出版信息
Org Lett. 2006 Jul 6;8(14):2901-4. doi: 10.1021/ol060481c.
PMID:16805512
Abstract
[reaction: see text] Asymmetric Michael additions of cyclohexanone to both aryl and alkyl nitroolefins in the presence of 20 mol % of organocatalyst 2b and 10 mol % of n-butyric acid afford adducts 5 with high diastereoselectivities and enantioselectivities.
摘要
[反应：见正文] 在20摩尔%的有机催化剂2b和10摩尔%的正丁酸存在下，环己酮与芳基和烷基硝基烯烃进行不对称迈克尔加成反应，得到具有高非对映选择性和对映选择性的加合物5。
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