Khan Mohamed K, Nigavekar Shraddha S, Minc Leah D, Kariapper Muhammed S T, Nair Bindu M, Lesniak Wojciech G, Balogh Lajos P
NanoBiotechnology Center at RPCI, Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Technol Cancer Res Treat. 2005 Dec;4(6):603-13. doi: 10.1177/153303460500400604.
Our results indicate that the surface chemistry, composition, and 3-D structure of nanoparticles are critical in determining their in vivo biodistribution, and therefore the efficacy of nanodevice imaging and therapies. We demonstrate that gold/dendrimer nanocomposites in vivo, present biodistribution characteristics different from PAMAM dendrimers in a B16 mouse tumor model system. We review important chemical and biologic uses of these nanodevices and discuss the potential of nanocomposite devices to greatly improve cancer imaging and therapy, in particular radiation therapy. We also discuss major issues confronting the use of nanoparticles in the near future, with consideration of toxicity analysis and whether biodegradable devices are needed or even desirable.
我们的研究结果表明，纳米颗粒的表面化学、组成和三维结构对于确定其体内生物分布至关重要，因此对于纳米装置成像和治疗的效果也至关重要。我们证明，在B16小鼠肿瘤模型系统中，金/树枝状聚合物纳米复合材料在体内呈现出与聚酰胺-胺（PAMAM）树枝状聚合物不同的生物分布特征。我们回顾了这些纳米装置的重要化学和生物学用途，并讨论了纳米复合装置在极大改善癌症成像和治疗（尤其是放射治疗）方面的潜力。我们还讨论了在不久的将来使用纳米颗粒所面临的主要问题，同时考虑了毒性分析以及是否需要甚至是否希望使用可生物降解的装置。
