Yates Tara D, Hebden Jeremy C, Gibson Adam P, Enfield Louise, Everdell Nicholas L, Arridge Simon R, Delpy David T
University College London, Department of Medical Physics & Bioengineering, London WC1E 6BT, United Kingdom.
J Biomed Opt. 2005 Sep-Oct;10(5):054011. doi: 10.1117/1.2063327.
A method has been devised for generating three-dimensional optical images of the breast using a 32-channel time-resolved system and a liquid-coupled interface. The breast is placed in a hemispherical cup surrounded by sources and detectors, and the remaining space is filled with a fluid with tissue-like optical properties. This approach has three significant benefits. First, cups can accommodate a large range of breast sizes, enabling the entire volume of the breast to be sampled. Second, the coupling of the source and detector optics at the surface is constant and independent of the subject, enabling intensity measurements to be employed in the image reconstruction. Third, the external geometry of the reconstructed volume is known exactly. Images of isolated targets with contrasting absorbing and scattering properties have been acquired, and the performance of the system has been evaluated in terms of the contrast, spatial resolution, and localization accuracy. These parameters were strongly dependent on the location of the targets within the imaged volume. Preliminary images of a healthy human subject are also presented, which reveal subtle heterogeneity, particularly in the distribution of scatter. The ability to detect an absorbing target adjacent to the breast is also demonstrated.
已设计出一种方法，使用32通道时间分辨系统和液体耦合界面来生成乳房的三维光学图像。将乳房置于一个由光源和探测器环绕的半球形杯中，其余空间填充具有类似组织光学特性的流体。这种方法有三个显著优点。第一，杯子能够容纳各种尺寸的乳房，从而能够对整个乳房体积进行采样。第二，表面处光源和探测器光学器件的耦合是恒定的且与受试者无关，这使得在图像重建中能够采用强度测量。第三，重建体积的外部几何形状是确切已知的。已获取具有对比吸收和散射特性的孤立目标的图像，并根据对比度、空间分辨率和定位精度对系统性能进行了评估。这些参数强烈依赖于目标在成像体积内的位置。还展示了一名健康人类受试者的初步图像，这些图像揭示了细微的异质性，尤其是在散射分布方面。还展示了检测乳房附近吸收性目标的能力。
