Enfield Louise C, Gibson Adam P, Everdell Nicholas L, Delpy David T, Schweiger Martin, Arridge Simon R, Richardson Caroline, Keshtgar Mohammad, Douek Michael, Hebden Jeremy C
Department of Medical Physics and Bioengineering, University College London, London, WC1E 6BT, UK.
Appl Opt. 2007 Jun 10;46(17):3628-38. doi: 10.1364/ao.46.003628.
Optical tomography is being developed as a means of detecting and specifying disease in the adult female breast. We present a series of clinical three-dimensional optical images obtained with a 32-channel time-resolved system and a liquid-coupled interface. Patients place their breasts in a hemispherical cup to which sources and detectors are coupled, and the remaining space is filled with a highly scattering fluid. A cohort of 38 patients has been scanned, with a variety of benign and malignant lesions. Images show that hypervascularization associated with tumors provides very high contrast due to increased absorption by hemoglobin. Only half of the fibroadenomas scanned could be observed, but of those that could be detected, all but one revealed an apparent increase in blood volume and a decrease in scatter and oxygen saturation.
光学断层扫描技术正在被开发用于检测和确定成年女性乳房中的疾病。我们展示了一系列通过32通道时间分辨系统和液体耦合界面获得的临床三维光学图像。患者将乳房放入一个与光源和探测器耦合的半球形杯中，其余空间填充高散射液体。对38名患有各种良性和恶性病变的患者进行了扫描。图像显示，由于血红蛋白吸收增加，与肿瘤相关的血管增生提供了非常高的对比度。扫描的纤维腺瘤中只有一半能够被观察到，但在那些能够被检测到的纤维腺瘤中，除了一个之外，所有都显示出血容量明显增加，散射和氧饱和度降低。
