Kalliala Ilkka, Anttila Ahti, Pukkala Eero, Nieminen Pekka
Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Box 140, FIN-00029, Helsinki, Finland.
BMJ. 2005 Nov 19;331(7526):1183-5. doi: 10.1136/bmj.38663.459039.7C.
To study the long term risk of cervical and other cancers after treatment for cervical intraepithelial neoplasia.
Retrospective cohort study.
University Hospital, Helsinki, Finland.
7564 women treated for cervical intraepithelial neoplasia during 1974 and 2001 and followed up through the Finnish cancer registry until 2003.
Standardised incidence ratio for cervical cancer and other cancers.
During follow-up 22 cases of invasive cervical cancer occurred in women treated for cervical intraepithelial neoplasia (standardised incidence ratio 2.8, 95% confidence interval 1.7 to 4.2). The highest risk was during the second decade (10 cases observed: 3.1, 1.5 to 5.7). The standardised incidence ratio for cervical intraepithelial cancer type 1 was 3.1 (1.4 to 6.2) and for type 2 was 3.7 (0.9 to 10.7).
The risk of cervical cancer in the first 20 years after treatment for cervical intraepithelial neoplasia is higher than in the average population. The risk of smoking related cancers is also increased.
研究宫颈上皮内瘤变治疗后发生宫颈癌及其他癌症的长期风险。
回顾性队列研究。
芬兰赫尔辛基大学医院。
1974年至2001年期间接受宫颈上皮内瘤变治疗的7564名女性,并通过芬兰癌症登记处随访至2003年。
宫颈癌及其他癌症的标准化发病率。
在随访期间,接受宫颈上皮内瘤变治疗的女性中有22例发生浸润性宫颈癌(标准化发病率2.8,95%置信区间1.7至4.2)。最高风险出现在第二个十年(观察到10例:3.1,1.5至5.7)。1型宫颈上皮内癌的标准化发病率为3.1(1.4至6.2),2型为3.7(0.9至10.7)。
宫颈上皮内瘤变治疗后的前20年患宫颈癌的风险高于一般人群。与吸烟相关癌症的风险也增加。