Ye Ping, D'Ercole A Joseph
Department of Pediatrics, The University of North Carolina at Chapel Hill, 27599-7220, USA.
J Neurosci Res. 2006 Jan;83(1):1-6. doi: 10.1002/jnr.20688.
Insulin-like growth factor-I (IGF-I) plays a key role in normal development. Recent studies show that IGF-I exerts a wide variety actions in the central nervous system during development as well as in adulthood. This report reviews recent developments on IGF-I actions and its mechanisms in the central nervous system, with a focus on its actions during the development of neural stem cells and progenitors. Available data strongly indicate that IGF-I shortens the length of the cell cycle in neuron progenitors during embryonic life and has an influence on the growth of all neural cell types. The phosphatidylinositol-3 kinase/Akt and mitogen-activated protein kinase pathways seem to be the predominant mediators of IGF-I-stimulated neural cell proliferation and survival. IGF-I actions, however, likely depend on cell type, developmental stage, and microenvironmental milieu.
胰岛素样生长因子-I（IGF-I）在正常发育过程中起关键作用。最近的研究表明，IGF-I在发育期间以及成年期的中枢神经系统中发挥多种作用。本报告回顾了IGF-I在中枢神经系统中的作用及其机制的最新进展，重点关注其在神经干细胞和祖细胞发育过程中的作用。现有数据有力地表明，IGF-I在胚胎期缩短神经元祖细胞的细胞周期长度，并对所有神经细胞类型的生长产生影响。磷脂酰肌醇-3激酶/蛋白激酶B（PI3K/Akt）和丝裂原活化蛋白激酶途径似乎是IGF-I刺激神经细胞增殖和存活的主要介质。然而，IGF-I的作用可能取决于细胞类型、发育阶段和微环境。
