Gutrecht J A
Department of Neurology, Lahey Clinic Medical Center, Burlington, Massachusetts 01805.
J Auton Nerv Syst. 1992 Jun 1;39(1):29-35. doi: 10.1016/0165-1838(92)90248-f.
Assessment of possible autonomic nervous system dysfunction was performed by testing cardiovascular reflexes in nine patients with progressive supranuclear palsy (PSP). The patients were significantly different from 15 control age-matched subjects because of greater blood pressure drop on standing for 1 min, diminished rise of diastolic blood pressure during the sustained handgrip test, and lack of compensatory tachycardia measured by the 30:15 ratio on standing. The latter test abnormality was caused by a slow rise to erect posture. No differences were observed in the cold pressor test, Valsalva ratio, and heart rate response to deep breathing. The differences between patients and control subjects were usually small. Autonomic nervous system involvement in patients with PSP is minor and is caused by involvement of central brain stem sympathetic nuclei or efferent fibers.
通过检测9例进行性核上性麻痹（PSP）患者的心血管反射，对可能存在的自主神经系统功能障碍进行了评估。这些患者与15名年龄匹配的对照受试者存在显著差异，原因在于站立1分钟时血压下降幅度更大、持续握力试验期间舒张压上升减弱，以及站立时通过30:15比率测量的代偿性心动过速缺乏。后一项测试异常是由于直立姿势时上升缓慢所致。在冷加压试验、瓦尔萨尔瓦比率以及深呼吸时的心率反应方面未观察到差异。患者与对照受试者之间的差异通常较小。PSP患者的自主神经系统受累程度较轻，是由中脑桥交感神经核或传出纤维受累引起的。
