心血管反射测试。年龄校正正常范围的评估。

Cardiovascular reflex tests. Assessment of age-adjusted normal range.

作者信息

Vita G, Princi P, Calabro R, Toscano A, Manna L, Messina C

出版信息

J Neurol Sci. 1986 Oct;75(3):263-74. doi: 10.1016/0022-510x(86)90074-2.

Abstract

To assess the relationship between aging and autonomic control of heart rate and blood pressure, cardiovascular reflex tests were performed in 70 healthy volunteers in the age range 25-71 years. R-R interval variation, heart rate change with deep breathing, 30/15 ratio and blood pressure response to standing appeared significantly declining with age. For each test we calculated the P0.99 and P0.01 confidence limits for individual observations. On the other hand, Valsalva ratio and the blood pressure response to sustained handgrip appeared to be unrelated to age. These results suggest that there is an age-dependent degradation of the mechanisms involved in the cardiovascular reflexes. The assessment of age-adjusted normal values improves the criteria for delineating abnormal from normal results in individual testing of autonomic function.

摘要

为评估衰老与心率和血压自主控制之间的关系，对70名年龄在25至71岁之间的健康志愿者进行了心血管反射测试。R-R间期变化、深呼吸时的心率变化、30/15比值以及站立时的血压反应均随年龄增长而显著下降。对于每项测试，我们计算了个体观察值的P0.99和P0.01置信限。另一方面，瓦尔萨尔瓦比值和持续握力时的血压反应似乎与年龄无关。这些结果表明，心血管反射所涉及的机制存在年龄依赖性退化。评估年龄校正后的正常值可改善在个体自主功能测试中区分异常与正常结果的标准。