1-芳基-5-苄基硫烷基四唑，一类针对潜在致病菌株的新型抗分枝杆菌化合物。
1-Aryl-5-benzylsulfanyltetrazoles, a new group of antimycobacterial compounds against potentially pathogenic strains.
作者信息
Waisser K, Adamec J, Dolezal R, Kaustová J
机构信息
Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czechia.
出版信息
Folia Microbiol (Praha). 2005;50(3):195-7. doi: 10.1007/BF02931565.
PMID:16295656
Abstract
A set of 21 1-phenyl-5-benzylsulfanyltetrazoles substituted on the phenyl ring as well as on the benzyl moiety was evaluated for in vitro antimycobacterial activity against Mycobacterium avium and two strains of M. kansasii. We tried to use the Hansch approach, the Free-Wilson approach and their combination for structure-activity correlation but the calculations were statistically insignificant.
摘要
对一组在苯环以及苄基部分上进行取代的21种1-苯基-5-苄基硫烷基四唑进行了体外抗鸟分枝杆菌和两株堪萨斯分枝杆菌的抗分枝杆菌活性评估。我们尝试使用汉施方法、自由威尔逊方法及其组合来进行构效关系研究，但计算结果在统计学上无显著意义。
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