新型抗分枝杆菌的2,3 - 二氢 - 1 - 烷基吲哚 - 2 - 硫酮
New antimycobacterial 2,3-dihydro-1-alkylindole-2-thiones.
作者信息
Waisser K, Heinisch L, Slosárek M, Janota J
机构信息
Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czechia.
出版信息
Folia Microbiol (Praha). 2006;51(1):25-6. doi: 10.1007/BF02931445.
A series of 2,3-dihydroindole-2-thiones was evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, M. kansasii, M. fortuitum, two strains of M. intracellulare and three strains of M. avium. 2,3-Dihydro-1-methyl-2-thioxoindole-3-one and 2,3-dihydro-1-butyl-2-thioxoindole-3-one were the most active substances against potentially pathogenic strains, being more active than isoniazide.
对一系列2,3-二氢吲哚-2-硫酮进行了体外抗分枝杆菌活性评估，测试对象包括结核分枝杆菌、堪萨斯分枝杆菌、偶然分枝杆菌、两株胞内分枝杆菌和三株鸟分枝杆菌。2,3-二氢-1-甲基-2-硫代氧代吲哚-3-酮和2,3-二氢-1-丁基-2-硫代氧代吲哚-3-酮是针对潜在致病菌株活性最强的物质，其活性比异烟肼还高。
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